Understanding the differences between the 3 ingredients for Gangnam skin boosters: HA, PDLLA, and PLLA

August 26, 2026

Hello.

I am Director Hwang, from Cleor Clinic Gangnam Branch.

When looking into skin boosters, there are so many names like Water Glow Injection, Juvelook, Rejuran, Exosomes, and Baby Injection,

but it hasn't been easy to decide which procedure is right for you, has it?

"I thought all skin boosters were the same,

but it turns out the ingredients and principles are completely different.

I want to understand how procedures that replenish moisture differ from those that build collagen,

and I want to organize and decide which ingredients are suitable for my skin."

I hear these questions in the consultation room quite often.

Although skin boosters are procedures that manage skin condition by injecting active ingredients into the dermis,

the principles and the direction of the results vary completely depending on which ingredients are used.

Methods that immediately replenish moisture to create volume,

methods that induce the skin to produce its own collagen,

and methods that strongly induce collagen regeneration over a long period

all approach from different ingredient categories.

Understanding the characteristics of these ingredients and choosing the right method significantly influences satisfaction with the results,

and the approach that helps with this decision is Gangnam Skin Booster.

Today, I will explain the principles and characteristic differences of the three representative ingredients used in skin boosters: HA, PDLLA, and PLLA,

and provide criteria for choosing the right ingredient according to your goals.

What is Gangnam Skin Booster?

👉 Gangnam Skin Booster is a category of procedures that manages skin condition and self-regeneration ability by injecting active ingredients into the dermis.

The principles and result directions differ by ingredient category, such as HA, PDLLA, and PLLA, so you can choose according to your goals.

Skin boosters are not procedures that create volume in specific areas like fillers.

It is a method of managing skin condition, moisture, elasticity, and regeneration ability by uniformly injecting active ingredients into shallow layers over the entire face or wide areas such as the neck and forehead.

At the Gangnam Branch, we operate skin booster options with various ingredient categories,


so you can choose the procedure that suits your skin condition and management goals.

In addition to HA-based Water Glow Injection and PDLLA-based Juvelook,

various ingredient options such as PN-based Rejuran/Filmed, Exosomes, and growth factors are available,

so you can combine them according to your skin concerns.

HA - Ingredients that immediately replenish moisture and volume

👉 HA stands for Hyaluronic Acid, a natural polysaccharide that originally exists in our body,

and it is a skin booster ingredient characterized by immediate moisture supply and volume recovery due to its powerful moisture absorption ability.

Principles and Characteristics

  • HA is short for Hyaluronic Acid.

It is an ingredient that originally exists in our body and is a natural polysaccharide that plays a role in retaining moisture within the dermis.

1g of HA has such powerful moisturizing power that it can theoretically hold up to 6L of water,

so when injected into the dermis, it immediately attracts moisture to establish volume and elasticity.

Immediate moisture supply, volume recovery, and elasticity improvement

Additionally, you can expect the effect of inducing self-collagen production (secondary effect).

When results appear

  • Moisture and volume can be seen immediately after the procedure.

It lasts for about 6 to 12 months, and the ingredient itself is naturally absorbed over time.

Safety Strengths

  • Since it is a naturally occurring ingredient, the risk of allergies and immune reactions is low,

and if a problem occurs, it can be immediately dissolved and controlled with an enzyme called Hyalase (hyaluronidase),

making it an ingredient with clear strengths in terms of safety.

At the Gangnam Branch, Water Glow Injection is used as an HA-based skin booster,

which is an approach that can address moisture, whitening, and elasticity together.

PDLLA - Ingredients that induce self-collagen production

👉 PDLLA is a synthetic polymer mixed with L-type and D-type isomers that stimulates fibroblasts in the dermis to

induce self-collagen production, making it a collagen booster ingredient.

Principles and Characteristics

  • PDLLA is short for Poly-D,L-Lactic Acid and is a synthetic polymer.

It has a structure in which L-type and D-type isomers are randomly mixed, so the human body can slowly decompose it,

and during the decomposition process, macrophage and fibroblast reactions are activated, and self-collagen production signals are transmitted.

Since a small amount of HA is contained, initial volume is seen immediately after the procedure,

and then the collagen reaction takes hold, creating natural volume and elasticity.

Main Functions

  • Induces self-collagen and elastin production

Complements immediate sensation with initial HA volume

Fundamental improvement through dermal remodeling

When results appear

  • Collagen reactions begin from 4 to 6 weeks, and clear results are established at the 3-month mark.

It lasts for about 12 to 18 months and is decomposed and excreted as carbon dioxide and water through the human metabolic process.

Safety Perspective

  • Since it is a synthetic polymer, it cannot be dissolved with Hyalase,

so the practitioner's precise layer placement and uniform distribution are particularly important for the stability of the results.

At the Gangnam Branch, Juvelook is used as a PDLLA-based skin booster,

which is a method that can approach natural water glow and elasticity through collagen production.

PLLA - Ingredients that strongly induce collagen regeneration over a long period

👉 PLLA is a synthetic polymer composed only of 100% L-type isomers, and thanks to its regular crystalline structure,

it is an ingredient that decomposes slowly in the human body, so self-collagen regeneration lasts strongly for a long time.

Principles and Characteristics

  • PLLA is short for Poly-L-Lactic Acid.

Although the name is similar to PDLLA, it is composed of 100% L-type without D-type,

forming a regular crystalline structure woven tightly like a grid.

Because this structure is a stable arrangement that is difficult for the human body to decompose,

the collagen stimulation reaction lasts for a long time and gradually takes hold.

Main Functions

  • Strongly induces self-collagen (strongest reaction)

Fundamental dermal remodeling

Long-term volume and elasticity recovery

When results appear

  • Collagen reactions begin from 6 to 12 weeks, and clear results are established from the 3-month mark.

Duration

  • It lasts up to 24 months, which is the longest duration among the three ingredients,

and clinical data showing that 80% of respondents maintained it for 24 months is confirmed.

Safety Perspective

  • Since it is a synthetic polymer, it cannot be dissolved with Hyalase,

and due to its slow decomposition characteristics, precise hydration and sophisticated layer placement before the procedure are decisive factors.

Representative PLLA-based procedures include Olidia and Sculptra,

but the Gangnam Branch does not operate PLLA-based skin boosters separately,

so related management inquiries will be reviewed for suitable alternative options during the preliminary consultation.

Comparison of the 3 ingredients at a glance

👉 Because HA, PDLLA, and PLLA have different principles, appearance times, duration, and safety,

the suitable ingredient is completely different depending on the management goal and individual situation.

Ingredient selection guide by goal

👉 Skin booster ingredient selection depends on management goals and result priorities,

and judgment is required from four perspectives: immediate results, long-term maintenance, safety, and fundamental recovery.

When immediate results are the priority - HA category

  • If you want to feel moisture and volume immediately after the procedure, the HA category is suitable.

It is often used when condition management from the perspective of dryness, fine lines, and tone improvement is needed,

or when skin soothing and moisture supplementation are needed before or after peeling or laser procedures.

When medium-term maintenance and natural collagen regeneration are the priority - PDLLA category

  • If you need fundamental collagen regeneration beyond moisture supply and 12 to 18 months of maintenance, the PDLLA category is suitable.

Since it has initial HA volume, there is a sensation immediately after the procedure,

and because it is a method where natural water glow and elasticity are created as the collagen reaction takes hold,

it is often chosen by those who want fundamental management while also wanting to see initial results.

When long-term maintenance is the priority - PLLA category

  • If you need long-term results that last up to 24 months with a single procedure, the PLLA category is effective.

Although the immediate results are not large, it is a flow that gradually takes hold over 6 to 12 weeks,

so it is suitable for those who want natural changes and want to lower the burden of re-procedures.

When safety and controllability are the priority - HA category

  • If you need the strength of safety from the perspective of being able to immediately dissolve and control it with Hyalase if a problem occurs,

the HA category is reviewed first.

It is often chosen when it is your first skin booster procedure or when you want to start with a lower burden.

Gangnam Skin Booster Lineup

👉 At the Gangnam Branch, in addition to HA-based Water Glow Injection and PDLLA-based Juvelook, we operate various skin booster options

including PN-based, Exosomes, and growth factor-based categories.

Generally, results are stably established when performed regularly 3 times or more at 2 to 4-week intervals,

and methods of combining procedures with different ingredient categories are also frequently reviewed.

We will look at the ingredients and number of sessions suitable for your skin condition and management goals together during the preliminary consultation.

Who is a good candidate for skin boosters?

Those who want to manage overall facial skin condition, moisture, and elasticity

  • Those who want to approach fine lines and skin tone improvement as regular management

  • Those who need fundamental management different from the local volume of fillers

  • Those who want long-term skin management through collagen regeneration

  • Those who want to understand the ingredients and principles and choose suitable options

  • Those who want to combine multiple ingredient categories for regular management

  • Gangnam Skin Booster side effects and things to know in advance

👉 Gangnam Skin Booster has different safety characteristics and response methods for each ingredient category, so understanding the characteristics of each ingredient when choosing a procedure

has a significant impact on satisfaction with the results.

Light redness, micro-swelling, thin bruising, and injection marks may remain on the treated area for a few days immediately after the procedure.

Generally, they naturally clear up within a few days to a week.

Since the HA category is a naturally occurring ingredient, the risk of allergies is low,

and it is an ingredient with clear strengths in terms of safety because it can be immediately dissolved and controlled with Hyalase if a problem occurs.

Since PDLLA and PLLA categories are synthetic polymers, they cannot be dissolved with Hyalase,

so the practitioner's precise layer placement and uniform distribution are particularly important for the stability of the results.

Following the guidance of experienced medical staff, the suitable ingredient and procedure intensity will be decided after checking your skin condition and status during the preliminary consultation.

Since collagen-based procedures have a flow where results gradually take hold,

there may not be a large immediate change right after the procedure,

but the results will gradually become clearer over time.

For 1 week after the procedure, it is good for recovery stability to refrain from strong massage, saunas, strenuous exercise, drinking, and smoking.

If any of the following apply to you, the procedure may be restricted or

preliminary confirmation may be required, so please inform us during the consultation.

If you are pregnant or breastfeeding

If there is active herpes, infection, or wounds on the treated area

If you have been diagnosed with an autoimmune disease or keloid constitution

If you are regularly taking anticoagulants or antiplatelet agents, or have a bleeding tendency

If you have a history of other filler or thread procedures on the treated area recently

  • If you have a history of allergies to specific ingredients

  • ⚠️ Precautions before and after skin booster procedures

  • 👉 Skin booster procedures are procedures where result uniformity and recovery speed vary depending on pre-procedure condition management and post-procedure UV and moisture management.

  • ❓ Frequently Asked Questions (FAQ)

  • Q. When can I see the results of Gangnam Skin Booster?

  • It depends on the ingredient category.

The HA category shows moisture and volume immediately after the procedure,

while the PDLLA category begins collagen reactions from 4 to 6 weeks, and the PLLA category from 6 to 12 weeks.

Q. Which one should I choose among HA, PDLLA, and PLLA?

It depends on your management goals and result priorities.

If immediate moisture and safety are the priority, the HA category is suitable;

if natural collagen regeneration and medium-term maintenance are the priority, the PDLLA category is suitable;

and if long-term maintenance and strong collagen regeneration are the priority, the PLLA category is suitable.

Q. Can I receive multiple ingredients combined?

Combinations where the principles do not overlap because the ingredient categories are different can be performed synergistically.

A combination that approaches immediate moisture/volume with HA and also takes self-collagen regeneration with PDLLA is frequently reviewed,

and it is good for result stability to maintain an interval of 4 weeks or more between procedures.

Q. Is there a difference in pain depending on the ingredient?

It is performed after applying anesthetic cream before the procedure, so there is not much strong pain.

It is a method of injecting small amounts into multiple points with a thin needle, so the burden is relatively low,

and the soreness after the procedure naturally clears up.

Q. Why is the procedure duration different?

It is because the human body's decomposition speed of the ingredients is different.

Since HA is a naturally occurring ingredient, it decomposes relatively quickly;

PDLLA is a synthetic polymer but has an irregular structure, so it has a medium speed;

and PLLA is characterized by the slowest decomposition and longest duration due to its regular crystalline structure.

Q. How are skin boosters and fillers different?

If fillers are local procedures that create immediate volume in specific areas,

skin boosters are procedures that manage skin condition and regeneration ability by injecting active ingredients into shallow layers over the entire face or wide areas.

Q. Does the Gangnam Branch have PLLA-based procedures?

The Gangnam Branch does not operate PLLA-based skin boosters separately.

If long-term collagen regeneration is the priority, suitable alternative options will be reviewed during the preliminary consultation,

and a similar collagen regeneration approach is possible with PDLLA-based Juvelook.

Q. What is the procedure cycle?

Generally, regular sessions of 3 times or more at 2 to 4-week intervals are recommended.

As the number of sessions accumulates, the results are stably established,

and 3-month intervals are often used for regular maintenance.

Even if the name is the same, skin boosters are a category where the principles and result directions are completely different depending on the ingredient.

Methods that replenish immediate moisture and volume, methods that induce self-collagen production,

and methods that strongly induce collagen regeneration over a long period

approach from different ingredient categories called HA, PDLLA, and PLLA, respectively.

Gangnam Skin Booster is a procedure where choosing the right ingredient according to your goals and management direction determines satisfaction with the results.

At the Gangnam Branch, in addition to HA-based Water Glow Injection and PDLLA-based Juvelook,

we operate various options including PN-based Rejuran/Filmed, Exosomes, and growth factor-based Baby Injection.

Although PLLA-based procedures are not operated separately at the Gangnam Branch,

a similar collagen regeneration approach is possible with PDLLA-based Juvelook,

and you can design a regular management plan by combining procedures with different ingredient categories.

We will check the direction suitable for your skin condition and management goals directly during the consultation.

If you want to understand the ingredient principles and choose a skin booster that suits your skin,

please feel free to visit Cleor Clinic Gangnam Branch.

Even before deciding on a procedure, you can look at the ingredient direction suitable for your skin condition

together through a preliminary consultation.

※ This content is for general information purposes, and results may vary by individual.

Please decide on accurate diagnosis and whether to proceed with the procedure through consultation with a specialist.

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